Supramolecular Chemistry & Catalysis
Inspired by enzymes we develop synthetic analogues with high selectivity and activity, that function in concert with natural biocatalysts.
Towards synthetic enzymes
At the Supramolecular Chemistry and Catalysis group, our research encompasses two interconnected yet distinct areas, both aimed at advancing the design of functional molecular and supramolecular systems. The first focuses on single-chain nanoparticles (SCNPs), where we investigate the fundamental principles of single-chain folding and explore their potential in green and bio-orthogonal catalysis鈥攔evealing how precise molecular architecture can unlock novel catalytic functions. The second area centers on dynamic covalent materials and radical ring-opening polymerization, with an emphasis on the self-assembly mechanisms that govern their structure and function. In this line of research, we conduct fundamental studies to understand and harness these behaviors in the context of degradable and circular materials, contributing to the development of next-generation sustainable materials. These topics are discussed in the following sections.
Single-chain polymeric nanoparticles
Our first line of research is inspired by enzymatic multistep synthesis as it occurs in nature. We combine small-molecule self-assembly with polymer chemistry to develop synthetic polymers that fold into well-defined, three-dimensional functional structures in aqueous environments. The resulting particles, typically ranging in size from 5 to 20 nm, are known as single-chain polymeric nanoparticles (SCPNs). Compartmentalization within SCPNs is achieved through the self-assembly of pendant recognition motifs along the polymer chains. By incorporating structural elements into the SCPNs, we achieve protein-like characteristics, unlocking the potential to create synthetic enzymes and sub-20 nm encapsulation systems.
Our aim is to explore the limits of SCPNs in terms of structural control, characterization, and application. Key areas of focus include environmental responsiveness, reversible folding and unfolding, and control over particle shape.
Our ultimate goals are to activate prodrugs selectively at diseased sites, thereby reducing the toxic side effects commonly associated with many drugs, and releasing active agents on demand through the incorporation of stimuli-responsive chemistry.
DYNAMIC COVALENT MATERIALS
Our second line of research addresses the global challenge posed by plastic materials that cannot be reused after damage or that persist in the environment without degrading. To tackle this issue, we introduce labile chemical bonds into carbon-based polymers or utilize dynamic covalent bonds that also form strong hydrogen bonds. In both approaches, our goal is to create novel materials with tunable degradation properties鈥攕o they do not accumulate in the environment鈥攐r with self-healing capabilities, allowing them to be reused. We are developing smart polymeric materials that can be easily reshaped, reused, and broken down into their constituent components. Our approach to dynamic networks is grounded in a deep understanding of the materials鈥� molecular properties. We primarily focus on siloxane-based, reprocessable, and reshapeable transparent, high-modulus dynamic covalent polymeric networks for use in coatings. Additionally, we leverage recent advancements in the copolymerization of vinyl-based monomers with cyclic ketene acetals via radical ring-opening
polymerization. This strategy enables the introduction of biodegradability into highly functional single-use formulation polymers and supports the development of degradable SCPNs. Ultimately, our goal is to apply insights from structure鈥損roperty relationships to enhance the practical applicability of these materials.
Meet some of our Researchers
Recent Publications
Our most recent peer reviewed publications
Contact
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Visiting address
Helix, STO 4.45Het KranenveldEindhovenNetherlands -
Visiting address
Helix, STO 4.45Het KranenveldEindhovenNetherlands -
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